Human immunodeficiency virus (HIV) that causes AIDS have been the most feared and devastating effects in the global community that started in 1981. For decades have still no signs of treatments. Extensive research going underway as it declared pandemic by World Health Organization. To date, funding of the research widened as the need arises from the increased number of HIV infections. But lately, getting best on discovery of gene therapy for HIV patients scores an early success.
Mostly, a team of scientist conducts the extensive research focus on immune cells because this was the area that forms a loveliest attack by the virus. Actually it is not the HIV that killed a patient but complications due to weakening immune system that there were what we called opportunistic infections such as bacterial, viral in nature and environmental factors.
Getting Best On Gene Therapy For Six Patients
Recently, a breakthrough on HIV therapy begun when the immune system started to produce immune cells free from the virus. The researchers engineered the method calling it a gene therapy. Encouraging results have been a success story of the six patients.
First, they obtained a sample cells infected with HIV from patients undergoing treatment of antiretroviral drugs. Second, they used Sangamo enzyme to disrupt the gene and instruct protein that HIV uses to enter cell. Third, the engineered cells were then infused back to the patients.
The results, 5 out of six patients increased their immune-cell counts tremendously. They believe that following this procedure many times to the patients, a high percentage of resistant cells could be established.
Due to inspiring clinical findings, the research has been extended to patients who are more in serious conditions. Hopefully gaining for a positive results.
Getting Best Out Of The ‘Beast’
It’s been 27 years, nearly 25 million people already died from AIDS that caused by HIV. In 2008, globally reaching 2 million peoples have died, 33 million more living with HIV, while almost 3 million are newly infected of the virus.
Deaths caused by the virus varied from different locations in the world but more than 90 percent of peoples living with HIV are in developing countries.
Peoples get affected from all ages, mostly from the prime years of their lives having a premature death. Even fetus still inside mother’s womb has already the virus that cut short the life of newly-born baby when parents became a carrier. The virus actually does not discriminate by age, race, gender, ethnicity, sexual orientation, or socio economic status. Everyone is susceptible. But there are certain risk groups identified, that is men having sex with men, injecting drug users, and commercial sex workers.
The impact of HIV to women is particularly devastating. Women now include the 50 percent of those aged 15 and older living with HIV.
The impact on HIV on children and young people is severe and growing problem. Children under age 15 were infected of HIV counted 430,000, while 280,000 died of AIDS.
Getting Best On The Effects Of Social Life
Wanting to know the real effects of having HIV is getting worst and not getting best in real life. For the reason that the real story is when the disease impacts a person it bounces back a devastating final result on a family and community.
Person with HIV started losing the skill to support, work, and provide for family needs. At the same time, remedy and health care costs related to HIV consume household incomes. The combine consequence of decreased income and increased costs results to weaken family financial standing.
Deepening socioeconomic and gender disparities. Women are at high risk of infection and have few alternatives for providing for their families. Children suffering from HIV/AIDS, as a result of their own infection or parental illness or death, are less probable to receive an education, as they leave school to care for ailing parents and younger siblings.
Straining the resources of communities – hospitals, social services, schools and businesses. Health care employees, teachers, and business and government leaders have been lost to HIV/AIDS. The affect of came down productivity is felt on a national scale.
Getting Best Fighting The Disease Through The Years
There was no formidable treatment for HIV to date. But looking the development stage, there was already a significant success going at the end of the tunnel, at least a big amount of kudos to those who are involves in the research development.
Stem cell transplantation was a big success in 2007 against HIV when a man undergoes bone marrow treatment due to leukemia. After 600 days without any taking antiretroviral drug, there was a significant reduction of HIV to the point that cannot be anymore detected. But still believe that there are still HIV living in other tissues of a man’s body. This method of treatment is not accepted as cure to HIV patients since of untrustworthy in nature and mortality risk in bone marrow transplants.
In 2010, virus inhibitors was introduced by Banlec but was not approved by FDA. It prevents entering of HIV into human cells. The discovery was having an impact on reduction of virus in attacking cells and tissues but only in the surface area like skin and vaginal infection.
Another discovery of virus inhibitors was the used of peptide almost the same with Banlec that prevents HIV in entering human cells. Clinical trial showed that 95 percent reduction of HIV in the human blood, but with the treatment it requires expensive and regular injections.
At present, researchers focus on immune system boosters. Aside from controlling viral replication, the immune system is the vulnerable one. The method of increasing the immune cells is much on focus to determine curability. This is how gene therapy obtained by Sangamo BioSciences turns out the good news has breakthrough.